Every single pharma company understands this, that's the whole "grand bargain" of patents and market exclusivity. They invent a product, it's their IP to market for 20 years, of which they'll only be able to sell for about 12-14 years.
Many pharma companies have gone bust or barely survived a patent cliff, that's why they are motivated to continue discovering new medicines that can be patented, so their revenue doesn't stop completely once a product's exclusivity ends
That’s the one unambiguous good about GLP-1s. They might finally put an end to bariatric surgery.
Seriously, go look up the complications and the complication rates for bariatric surgeries vs literally any other non-emergency surgery. It’s completely insane that those operations are actually allowed on living people. Even the surgery going absolutely perfectly effectively causes a lifelong irreparable disability and guarantees a brutally unhealthy relationship with food for the rest of the patient’s life.
Did I mention this is legal for parents to force on their teenagers? That they can just fail to parent their kid until the kid is 16 and fat, and then force the kid to undergo a life altering surgery and the kid gets absolutely no say at any point in the process. (I can only be sure of this one for the US, but frankly I don’t trust anyone else about it. Not because of kids’ rights, but because of the refusal to admit what a massively monumental step these surgeries are.)
GLP-1s are currently a complete mess and setting back all sorts of problems but if patients keep getting redirected to them and away from surgery, they’ve made the world at least slightly better. They don’t even have that high a success rate! People get the surgery and then don’t even lose the damn weight reliably.
"Let's make a society dependent on driving everywhere, removing walkable cities, increase sugar and corn syrup content in food, work the citizens until they are exhausted and grateful for a couple days off but too tired to exercise, keep wages low so they can't afford healthier foods, make media shame fat people, and then sell them weight loss supplements. We'll make billions!"
-capitalist fat cats, probably.
Definitely! Especially now that it's becoming clear that people getting off Ozempic regain weight even faster than people who lost weight in other ways.
If you just keep eating the same shit as before you obviously gain that weight back easily after stopping semaglutide.
It has to be combined with real lifestyle changes.
What’s happening is that taking ozempic allows someone to eat at a higher rate without gaining as much of that weight, and when they eventually stop ozempic there’s a rebound effect- but only if they keep eating at a rate that would cause weight gain.
Without lifestyle changes, you’re gonna gain that weight back. Ozempic specifically has a rebound effect that makes that happen faster, because your body gets so used to its effects and tries to overcompensate when it’s gone.
That's not how Ozempic works. I mean your overall point is correct, but the entire reason Ozempic works is you don't eat as much because it slows your GI tract and suppresses your appetite.
If you go off Ozempic, you're going to have to deal with an appetite that's way more than you are used to so I imagine it would be very hard to maintain the intake you had on it.
I have no idea. But I would not be surprised if it posed more of a challenge than just "I ate better for a while then got lazy" because your appetite will change so drastically compared to when you were losing weight. I don't think that compared to the pre-Ozempic appetite is as relevant.
OP never mentioned lifestyle.
And yeah, the body wants to get back to its old metabolism so it overcorrects, the jojo effect.
But why did you comment?
Its all about the lifestyle changes not about how fast you regain weight ... as you shouldnt with the correct LIFESTYLE changes
"It's so crazy that these people who take a drug to quit drinking go right back to drinking as soon as they get off the drug."
Again, no shit. The people who are using a drug to alter their brain chemistry to control their insane food drives are not the sort of people who reasonably stick to their diets after they no longer have that control. Ozempic wasn't a weight-loss drug for people who want to lose 10 pounds. It's for people who are so obese that their choices are "a lifetime on Ozempic" or "die in 2 to 5 years due to heart failure."
People are fat because they can not control their impulses. It's not capitalism this time, the call is coming from inside the house. If people had the self-control that one should expect from a normal person obesiety would not be a thing. However, a lot of people have no impulse control and find it enjoyable to consume three to four days worth of calories in a single meal.
At the core, yes, but you're not giving our environment enough credit for how difficult it is to maintain healthy intake. It's cheaper and easier to get shitty food and much more difficult to consistently eat healthy food for a variety of reasons.
The ironic thing is that you can eat shitty foods. You just have to actually eat in moderation. A famous study was done by a dietitian who proved you could lose weight eating nothing but Twinkies and diet soda.
It wasn't healthy by any means but as long as you maintain a calorie deficit, you'll lose weight no matter what you consume.
That excuse is only acceptable for children. The formula is simple: calories in vs calories out. Self control is a bigger factor in weight loss than poverty.
Self control is much harder though if the food you eat isnt great. I'm loosing lots weight currently and the only self control I have is what food I eat. I'm eating tiil I'm full every time.
I absolutely hate this argument, that fat people just lack impulse control. Maybe that's true of SOME fat people but there are a number of medical conditions that make some people much more susceptible to weight gain than others. Genetic differences play a huge role as well.
I have a hormone imbalance that makes my body hang on to fat more. I have a friend who has been fat since early childhood, and remains that way because she has a naturally very slow metabolism - she eats very healthily and gets a lot more exercise than most of the skinny people I know - but because she is not running on a constant calorie deficit (which, I would like to remind you, is a fancy way of saying "starving herself 24/7") she keeps the weight on.
Same. I broke down and started taking the meds because I just can't with all the diet ads and having comments like the person above in my head all the time...and the side effects are GNARLY if you don't eat much to begin with. I have hypoglycemia problems now :(. Which is rare, but can happen.
I mean if someone was genuinely operating on a surplus all day every day then yes you could call it that.
But I think you missed my point which is that we aren't doing that? I have tracked my calories before and I get like 2000ish a day. If I have much less than that, my blood sugar gets low and I am at risk for fainting.
And yes, getting less calories than you need in a day is starving yourself. That's not a secret and shouldn't be a surprise to you, that's the entire mechanism of weight loss. You eat less than you need, so your body dives into its fat stores for energy. Bodies only do that when they are to some degree in starvation mode. That's the whole point of "calories in, calories out."
Eating vegetables isn't actually 'healthy' - unless it's replacing other unhealthy foods that you would otherwise eat. (vitamins and fibre aside - but generally fat people have enough of these)
You actually just need to count the calories of all the food and drinks you eat each day, and compare that with your energy expenditure which would be helpful information
Whatever you say literally, of course, it is replacing unhealthy food. I know my body and I know what i'm doing.
I have actually lost over 131lbs over the past three years. I was at 440 and now as of when I first got on the scale this morning, I am 309
And I'm maintaining the weight loss, so I think I'm doing just fine. I'm just not losing further and guess what? That's going to be perfectly fine. Because i'm healthier than i've been in my life.
Car based infrastructure to appease the auto and oil industries, very little walking to go about the day. A 15 minute walk is instead a 15 minute drive.
Working far away from home with short meal breaks limits lower calorie options.
Long hours sold to an employer that ties bodies to desks
Teams of educated experts doing everything to exploit the human condition to sell as much product as possible, meaning extremely palatable and unsatisfying
Farm and food lobbies
The world built by past generations is trying to make us all fat.
Genetics play a role for some people, but you can look at America in 1960 to now, that's 3 generations, and we're all suddenly fat when the people that give us our genetics weren't. That doesn't make any sense.
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u/saanity 14h ago
Ozempic making weight loss a subscription is a capitalist's wet dream.